
Director of Clinical Services
Professor of Clinical Psychiatry
Psychiatry UCSF
+1 415 502-7800
My research and clinical work has largely focused on psychiatric aspects of developmental disorders, and upon the pathogenesis and treatment of significant behavioral disturbance in autism and related disorders in particular. In recent years, this focus has been primarily directed on interventions in autism including both pharmacological and psychosocial treatments.
Publications
Overlap of genetic factors among craniosynostosis and autism spectrum disorder: the presence of autistic cases without craniosynostosis in carriers of shared variants.
Journal of neurosurgery. Pediatrics
Predictors of Placebo Response in the Study of Oxytocin in Autism to Improve Reciprocal Social Behaviors.
Journal of child and adolescent psychopharmacology
PHARMACOLOGICAL MANAGEMENT OF MALADAPTIVE BEHAVIORS IN ASD WITH COMORBID PSYCHOPATHOLOGY.
Journal of the American Academy of Child & Adolescent Psychiatry
The Human Phenotype Ontology in 2024: phenotypes around the world.
Nucleic acids research
Diagnosis and Management of Comorbidities in ASD.
Journal of the American Academy of Child & Adolescent Psychiatry
Genetic and epigenetic signatures associated with plasma oxytocin levels in children and adolescents with autism spectrum disorder.
Autism research : official journal of the International Society for Autism Research
Adaptive Behavior in Young Autistic Children: Associations with Irritability and ADHD Symptoms.
Journal of autism and developmental disorders
A MULTIDIMENSIONAL APPROACH TO MANAGING MOOD AND BEHAVIOR IN ASD.
Journal of the American Academy of Child & Adolescent Psychiatry
AN UPDATE ON COMMON COMORBIDITIES IN ASD: SLEEP DISORDERS, ANXIETY, BODY-FOCUSED REPETITIVE BEHAVIORS, AND IRRITABILITY.
Journal of the American Academy of Child & Adolescent Psychiatry
Citalopram Did Not Significantly Improve Anxiety in Children with Autism Spectrum Disorder Undergoing Treatment for Core Symptoms: Secondary Analysis of a Trial to Reduce Repetitive Behaviors.
Journal of child and adolescent psychopharmacology
Adolescents With Eating Disorders in Pediatric Practice - The European Academy of Paediatrics Recommendations.
Frontiers in pediatrics
Intranasal Oxytocin in Children and Adolescents with Autism Spectrum Disorder.
The New England journal of medicine
AUTISM SPECTRUM DISORDER: MANAGEMENT OF SEVERE BEHAVIORAL AND MOOD DISORDERS.
Journal of the American Academy of Child & Adolescent Psychiatry
Predictors of Caregiver Strain for Parents of Children with Autism Spectrum Disorder.
Journal of autism and developmental disorders
Gender Differences in Treatment-Seeking Youth with Autism Spectrum Disorder.
Journal of Child and Family Studies
AUTISM SPECTRUM DISORDER: MANAGING AGGRESSION, AFFECTIVE LABILITY, SELF-INJURIOUS BEHAVIOR, AND SUICIDALITY IN THE OUTPATIENT SETTING.
Journal of the American Academy of Child & Adolescent Psychiatry
NEUROGENETIC SYNDROMES ASSOCIATED WITH AUTISM SPECTRUM DISORDER.
Journal of the American Academy of Child & Adolescent Psychiatry
Rationale, design, and methods of the autism centers of excellence (ACE) network study of oxytocin in autism to improve reciprocal social behaviors (SOARS-B).
Contemporary clinical trials
Practice Parameter for the Assessment and Treatment of Psychiatric Disorders in Children and Adolescents With Intellectual Disability (Intellectual Developmental Disorder).
Journal of the American Academy of Child and Adolescent Psychiatry
COMPLEX PRESENTATIONS OF ASD: BEYOND THE CORE FEATURES.
Journal of the American Academy of Child & Adolescent Psychiatry
OUTPATIENT MANAGEMENT OF IRRITABILITY, IMPULSIVE AGGRESSION, AND OTHER SEVERE BEHAVIORS IN YOUTH WITH ASD.
Journal of the American Academy of Child & Adolescent Psychiatry
Overemphasis of the Autism Diagnostic Observation Schedule (ADOS) Evaluation Subverts a Clinician's Ability to Provide Access to Autism Services.
Journal of the American Academy of Child and Adolescent Psychiatry
Developmental social vulnerability as the intrinsic origin of psychopathology: A paradigm shift from disease entities to psychiatric derivatives within human diversity.
Medical hypotheses
An Observational Study With the Janssen Autism Knowledge Engine (JAKE®) in Individuals With Autism Spectrum Disorder.
Frontiers in neuroscience
An exploration of concomitant psychiatric disorders in children with autism spectrum disorder.
Comprehensive psychiatry
A randomized, placebo-controlled trial of extended-release guanfacine in children with autism spectrum disorder and ADHD symptoms: an analysis of secondary outcome measures.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Autism spectrum disorder: Consensus guidelines on assessment, treatment and research from the British Association for Psychopharmacology.
Journal of psychopharmacology (Oxford, England)
21.0 Inpatient Treatment of Children With Autism and Intellectual Disability: Three Innovative Models.
Journal of the American Academy of Child & Adolescent Psychiatry
Disruption to control network function correlates with altered dynamic connectivity in the wider autism spectrum.
NeuroImage. Clinical
Arbaclofen in Children and Adolescents with Autism Spectrum Disorder: A Randomized, Controlled, Phase 2 Trial.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
4.6 Updates on Co-Occurring Conditions With Neurodevelopmental Disorders: Recognition and Treatment.
Journal of the American Academy of Child & Adolescent Psychiatry
7.2 Diagnostic Assessment for Autism Spectrum Disorder.
Journal of the American Academy of Child & Adolescent Psychiatry
Autism Spectrum Disorder: From Clinical Assessment to Novel Treatments.
Journal of the American Academy of Child & Adolescent Psychiatry
Severity of ASD symptoms and their correlation with the presence of copy number variations and exposure to first trimester ultrasound.
Autism research : official journal of the International Society for Autism Research
Psychiatric comorbidities in neurodevelopmental disorders.
Current opinion in neurology
Assessing Risk of Autism Spectrum Disorder in Children After Antidepressant Use During Pregnancy.
JAMA pediatrics
Unequal Individual Risk and Potential Benefit Balanced by Benefits to the Population at Large in Autism Clinical Trials?
The American journal of bioethics : AJOB
Focus on Autism and Related Conditions.
Focus (American Psychiatric Publishing)
Children with autism spectrum disorder and social skills groups at school: a randomized trial comparing intervention approach and peer composition.
Journal of child psychology and psychiatry, and allied disciplines
Extended-Release Guanfacine for Hyperactivity in Children With Autism Spectrum Disorder.
The American journal of psychiatry
The relationship between treatment attendance, adherence, and outcome in a caregiver-mediated intervention for low-resourced families of young children with autism spectrum disorder.
Autism : the international journal of research and practice
Factor structure and psychometric properties of the revised Home Situations Questionnaire for autism spectrum disorder: The Home Situations Questionnaire-Autism Spectrum Disorder.
Autism : the international journal of research and practice
TET1 is a tumor suppressor of hematopoietic malignancy.
Nature immunology
Tuberous sclerosis associated neuropsychiatric disorders (TAND) and the TAND Checklist.
Pediatric neurology
The peer relationships of girls with ASD at school: comparison to boys and girls with and without ASD.
Journal of child psychology and psychiatry, and allied disciplines
Measuring anxiety as a treatment endpoint in youth with autism spectrum disorder.
Journal of autism and developmental disorders
Sunsetting DSM-IV's pervasive developmental disorder.
Journal of the American Academy of Child and Adolescent Psychiatry
STX209 (arbaclofen) for autism spectrum disorders: an 8-week open-label study.
Journal of autism and developmental disorders
Update on diagnostic classification in autism.
Current opinion in psychiatry
Side effects from use of one or more psychiatric medications in a population-based sample of children and adolescents.
Journal of child and adolescent psychopharmacology
Practice parameter for the assessment and treatment of children and adolescents with autism spectrum disorder.
Journal of the American Academy of Child and Adolescent Psychiatry
Community child psychiatric medication experiences measured by an internet-based, prospective parent survey of retail pharmacy customers.
Community mental health journal
Measuring repetitive behaviors as a treatment endpoint in youth with autism spectrum disorder.
Autism : the international journal of research and practice
Mice exposed to diagnostic ultrasound in utero are less social and more active in social situations relative to controls.
Autism research : official journal of the International Society for Autism Research
Children's Yale-Brown obsessive compulsive scale in autism spectrum disorder: component structure and correlates of symptom checklist.
Journal of the American Academy of Child and Adolescent Psychiatry
Training of child and adolescent psychiatry fellows in autism and intellectual disability.
Autism : the international journal of research and practice
Exploring the manifestations of anxiety in children with autism spectrum disorders.
Journal of autism and developmental disorders
Tuberous sclerosis complex diagnostic criteria update: recommendations of the 2012 Iinternational Tuberous Sclerosis Complex Consensus Conference.
Pediatric neurology
Tuberous sclerosis complex surveillance and management: recommendations of the 2012 International Tuberous Sclerosis Complex Consensus Conference.
Pediatric neurology
Autism and developmental disorders: management of serious behavioral disturbance.
Child and adolescent psychiatric clinics of North America
Psychiatric assessment of severe presentations in autism spectrum disorders and intellectual disability.
Child and adolescent psychiatric clinics of North America
Outcome measures for clinical trials in fragile X syndrome.
Journal of developmental and behavioral pediatrics : JDBP
DSM-5 and autism: kicking the tires and making the grade.
Journal of the American Academy of Child and Adolescent Psychiatry
Fear-potentiated startle response is unrelated to social or emotional functioning in adolescents with autism spectrum disorders.
Autism research : official journal of the International Society for Autism Research
Revisiting the relationship between autism and schizophrenia: toward an integrated neurobiology.
Annual review of clinical psychology
Consensus paper: pathological role of the cerebellum in autism.
Cerebellum (London, England)
Commentary from the DSM-5 Workgroup on Neurodevelopmental Disorders.
Journal of the American Academy of Child and Adolescent Psychiatry
Intellectual Disability (Mental Retardation).
Clinical Child Psychiatry
Design and subject characteristics in the federally-funded citalopram trial in children with pervasive developmental disorders.
Journal of autism and developmental disorders
Reduced transcript expression of genes affected by inherited and de novo CNVs in autism.
European journal of human genetics : EJHG
Is schizophrenia on the autism spectrum?
Brain research
The association between short and long nocturnal sleep durations and risky behaviours and the moderating factors in Taiwanese adolescents.
Psychiatry research
Factor structure of the Athens Insomnia Scale and its associations with demographic characteristics and depression in adolescents.
Journal of sleep research
Lack of efficacy of citalopram in children with autism spectrum disorders and high levels of repetitive behavior: citalopram ineffective in children with autism.
Archives of general psychiatry
Pharmacology and genetics of autism: implications for diagnosis and treatment.
Personalized medicine
Asperger's syndrome: diagnosis and treatment.
The American journal of psychiatry
An update on pharmacologic treatments for autism spectrum disorders.
Child and adolescent psychiatric clinics of North America
Mental Retardation.
Clinical Child Psychiatry, Second Edition
Autism spectrum disorders: emerging pharmacotherapy.
Expert opinion on emerging drugs
Consensus clinical guidelines for the assessment of cognitive and behavioural problems in Tuberous Sclerosis.
European child & adolescent psychiatry
International Review of Research in Mental Retardation
The role of the basal ganglia in the expression of stereotyped, self-injurious behaviors in developmental disorders.
Outcome measures for clinical drug trials in autism.
CNS spectrums
The Role of the Basal Ganglia in the Expression of Stereotyped, Self-Injurious Behaviors in Developmental Disorders.
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Asperger syndrome: to be or not to be?
Current opinion in pediatrics
Maladaptive behaviour in children and adolescents with Down's syndrome.
Journal of intellectual disability research : JIDR
Psychopharmacology in mental retardation.
Current opinion in psychiatry
The quality of health care for adults with developmental disabilities.
Public health reports (Washington, D.C. : 1974)
Treatment of pain in acutely burned children.
The Journal of burn care & rehabilitation
Pharmacotherapy in mental retardation
Current opinion in psychiatry
Autism spectrum disorders: update of evaluation and treatment.
Current psychiatry reports
Self-injurious behavior in mental retardation.
Current opinion in psychiatry
Case series: amantadine open-label treatment of impulsive and aggressive behavior in hospitalized children with developmental disabilities.
Journal of the American Academy of Child and Adolescent Psychiatry
Double-blind, placebo-controlled study of amantadine hydrochloride in the treatment of children with autistic disorder.
Journal of the American Academy of Child and Adolescent Psychiatry
Self-injurious behavior: gene-brain-behavior relationships.
Mental retardation and developmental disabilities research reviews
Self-injurious behaviour in mental retardation
Current opinion in psychiatry
Pharmacological treatment of mood disturbances, aggression, and self-injury in persons with pervasive developmental disorders.
Journal of autism and developmental disorders
Expert Consensus Guideline Series: Treatment of psychiatric and behavioral problems in mental retardation.
American journal of mental retardation : AJMR
Carbamazepine reduces dopamine-mediated behavior in chronic neuroleptic-treated and untreated rats: implications for treatment of tardive dyskinesia and hyperdopaminergic states.
Experimental and clinical psychopharmacology
Pharmacologic management of psychiatric and behavioral symptoms in mental retardation.
Child and adolescent psychiatric clinics of North America
Practice parameters for the assessment and treatment of children, adolescents, and adults with mental retardation and comorbid mental disorders. American Academy of Child and Adolescent Psychiatry Working Group on Quality Issues.
Journal of the American Academy of Child and Adolescent Psychiatry
Summary of the Practice Parameters for the Assessment and Treatment of Children, Adolescents, and Adults with Mental Retardation and Comorbid Mental Disorders. American Academy of Child and Adolescent Psychiatry.
Journal of the American Academy of Child and Adolescent Psychiatry
Erratum: Association of an X-chromosome dodecamer insertional variant allele with mental retardation.
Molecular Psychiatry
Obsessive-compulsive symptoms in Prader-Willi and "Prader-Willi-Like" patients.
Journal of the American Academy of Child and Adolescent Psychiatry
Cortical damage enhances pemoline-induced self-injurious behavior in prepubertal rats.
Pharmacology, biochemistry, and behavior
Maladaptive behavior differences in Prader-Willi syndrome due to paternal deletion versus maternal uniparental disomy.
American journal of mental retardation : AJMR
Selective serotonin re-uptake inhibitors in intellectual disability
Mental retardation and developmental disabilities research reviews
Selective serotonin reuptake inhibitors in intellectual disability.
Developmental Disabilities Research Reviews
Association of an X-chromosome dodecamer insertional variant allele with mental retardation.
Molecular Psychiatry
Molecular screening for proximal 15q abnormalities in a mentally retarded population.
Journal of medical genetics
Paroxetine treatment of aggression and self-injury in persons with mental retardation.
American journal of mental retardation : AJMR
Developmental aspects of stereotyped movement disorder
Psychiatric Annals
Dopaminergic and glutamatergic interactions in the expression of self-injurious behavior.
Developmental neuroscience
Open-label olanzapine treatment in five preadolescent children.
Journal of child and adolescent psychopharmacology
Proton MR spectroscopy in four patients with Lesch-Nyhan Disease
American Journal of Neuroradiology
Self-injurious behaviour in mental retardation
Current opinion in psychiatry
Mental retardation: a review of the past 10 years. Part I.
Journal of the American Academy of Child and Adolescent Psychiatry
Mental retardation: a review of the past 10 years. Part II.
Journal of the American Academy of Child and Adolescent Psychiatry
Issues to consider in deaf and hard-of-hearing patients. The Committee on Disabilities of the Group for the Advancement of Psychiatry.
American family physician
Eating themselves to death: have "personal rights" gone too far in treating people with Prader-Willi syndrome?
Mental retardation
Child and learning disability psychopharmacology.
Journal of psychopharmacology (Oxford, England)
Pemoline alters dopamine modulation of synaptic responses of neostriatal neurons in vitro.
Developmental neuroscience
Pemoline produces ipsilateral turning behavior in unilateral 6-OHDA-lesioned rats.
Progress in neuro-psychopharmacology & biological psychiatry
Buspirone treatment of aggression and self-injury in autistic and non autistic persons with severe mental retardation
Developmental Brain Dysfunction
Open trial lamotrigine in the treatment of self-injurious behavior in an adolescent with profound mental retardation.
Journal of child and adolescent psychopharmacology
Dr. King and Colleagues Reply.
American Journal of Psychiatry
Pretreatment with MK-801 inhibits pemoline-induced self-biting behavior in prepubertal rats.
Developmental neuroscience
Psychiatric consultation in severe and profound mental retardation.
The American journal of psychiatry
Simple versus Complex Conduct Disorders: Identification and Phenomenology.
Behavioral Disorders
Simple versus complex conduct disorders: Identification and phenomenology
Behavioral Disorders
Self-injury by people with mental retardation: a compulsive behavior hypothesis.
American journal of mental retardation : AJMR
Low-dose naltrexone inhibits pemoline-induced self-biting behavior in prepubertal rats.
Journal of child and adolescent psychopharmacology
Hyperserotoninemia and antiserotonin antibodies in autism and other disorders.
Journal of autism and developmental disorders
Comments on self-injurious behaviour.
The American journal of psychiatry
Deficiency in the opioid hypotheses of self-injurious behavior.
American journal of mental retardation : AJMR
5-Hydroxytryptamine (5-HT)-induced shape change in human platelets determined by computerized data acquisition: correlation with [125I]-iodoLSD binding at 5-HT2 receptors.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
Fluoxetine reduced self-injurious behavior in an adolescent with mental retardation.
Journal of child and adolescent psychopharmacology
Hypothesis: involvement of the serotonergic system in the clinical expression of monosymptomatic hypochondriasis.
Pharmacopsychiatry
Proposals for the mechanism of action of convulsive therapy: a synthesis.
Biological psychiatry
MK-212 increases rat plasma ACTH concentration by activation of the 5-HT1C receptor subtype.
Neuroscience letters
Lies and liars: psychiatric aspects of prevarication.
The American journal of psychiatry
Pseudologia fantastica.
Acta psychiatrica Scandinavica
Therapeutic sleep deprivation for depression in children.
Journal of the American Academy of Child and Adolescent Psychiatry
Pseudologia Fantastica.
American Journal of Psychiatry
Pseudologia fantastica.
The American journal of psychiatry